Title:
【発明の名称】局所使用のためのアシクロビル誘導体
Document Type and Number:
Japanese Patent JPH11507642
Kind Code:
A
Abstract:
Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate, acyclovir diphosphate, and acyclovir triphosphate which show increased activity against native strains of herpes virus as well as against resistant strains, particularly thymidine kinase negative strains of virus. Also disclosed are methods for treatment of herpes infections with nucleoside phosphates. Anti-herpes nucleoside analogues phosphate esters include the phosphoramidates and phosphothiorates, as well as polyphosphates comprising C and S bridging atoms.
Inventors:
Hostler Karl Wai.
Application Number:
JP50219497A
Publication Date:
July 06, 1999
Filing Date:
June 06, 1996
Export Citation:
Assignee:
Hostler Karl Wai.
International Classes:
A61K9/70; A61K31/675; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7076; A61P31/12; C07D473/18; A61P31/22; C07F9/6524; C07F9/6527; C07H19/04; C07H19/10; C07H19/20; (IPC1-7): C07F9/6524; A61K9/70; A61K31/675; A61K31/70; C07D473/18; C07F9/6527; C07H19/10; C07H19/20
Attorney, Agent or Firm:
Eiji Saegusa (2 others)