Title:
【発明の名称】ピペリジン及びモルホリン誘導体並びに治療剤としてのそれらの使用
Document Type and Number:
Japanese Patent JPH11508552
Kind Code:
A
Abstract:
PCT No. PCT/GB96/01477 Sec. 371 Date Dec. 18, 1997 Sec. 102(e) Date Dec. 18, 1997 PCT Filed Jun. 20, 1996 PCT Pub. No. WO97/01554 PCT Pub. Date Jan. 16, 1997The present invention provides compounds of formula (I), wherein R1 is phenyl or a 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms, selected from nitrogen, oxygen and sulphur, which aryl or heteroaryl group is optionally substituted; R2 is hydrogen, halogen, C1-6alkyl, C1-6alkoxy, CF3, OCF3, NO2, CN, SRa, SORa, SO2Ra, CO2Ra, CONRaRb, C2-6alkenyl, C2-6alkynyl or C1-4alkyl substituted by C1-4alkoxy, where Ra and Rb each independently represent hydrogen or C1-4alkyl; R4, R5, R6, R9a and R9b, A, X, and Y are as defined in the specification; the dotted line is an optional double bond; Q1 is oxygen, sulphur or -NH-; Q2 is -N=, -NH-, -CH= or -CH2-; and m is zero or 1; and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.
Inventors:
Baker, Raymond
Elliott, The Eason
Steven Sunn, Graeme Irvine
Swain, Christopher Jiyoung
Elliott, The Eason
Steven Sunn, Graeme Irvine
Swain, Christopher Jiyoung
Application Number:
JP50422597A
Publication Date:
July 27, 1999
Filing Date:
June 20, 1996
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
C07D405/12; A61K31/443; A61K31/445; A61P25/04; A61P25/06; C07D405/14; (IPC1-7): C07D405/12; A61K31/445; C07D405/14
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)