Title:
【発明の名称】タンパク質チロシンキナーゼ阻害剤としての二環式複素芳香族化合物
Document Type and Number:
Japanese Patent JPH11513398
Kind Code:
A
Abstract:
Substituted heteroaromatic compounds of formula (A) wherein X is N or CH; in which (a) represents a fused 5, 6 or 7-membered heterocyclic ring and R3 is a group ZR4 wherein Z is joined to R4 through a (CH2)p group in which p is 0, 1, or 2 and Z represents a group V(CH2), V(CF2), (CH2)V, (CF2)V, V(CRR'), V(CHR) or V where R and R' are each C1-4 alkyl and in which V is a hydrocarbyl group containing 0, 1 or 2 carbon atoms, carbonyl, dicarbonyl, CH(OH), CH(CN), sulphonamide, amide, O, S(O)m or NRb where Rb is hydrogen or Rb is C1-4 alkyl; and R4 is an optionally substituted C3-6 cycloalkyl or an optionally substituted 5, 6, 7, 8, 9 or 10-membered carbocyclic or heterocyclic moiety; or R3 is a group ZR4 in which Z is NRb, and NRb and R4 together form an optionally substituted 5, 6, 7, 8, 9 or 10-membered carbocyclic or heterocyclic moiety, are protein tyrosine kinase inhibitors. The compounds are described, as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of psoriasis, fibrosis, atherosclerosis, restenosis, auto-immune disease, allergy, asthma, transplantation rejection, inflammation, thrombosis, nervous system diseases, and cancer.
Inventors:
George, Stuart, Cocaril
Stephen, Barry, Gun Trip
Stephen, Karl, McKeon
Martin, john, page
Kathryn, Jane, Smith
Sardier, bile
Alan, Thomas, Hudson
Paul, Balaklav
Karl, Beetle, Franz Mann
Stephen, Barry, Gun Trip
Stephen, Karl, McKeon
Martin, john, page
Kathryn, Jane, Smith
Sardier, bile
Alan, Thomas, Hudson
Paul, Balaklav
Karl, Beetle, Franz Mann
Application Number:
JP51471197A
Publication Date:
November 16, 1999
Filing Date:
October 10, 1996
Export Citation:
Assignee:
GLAXO GROUP LTD.
International Classes:
A61K31/00; A61K31/505; A61K31/519; A61K31/529; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P35/00; A61P43/00; C07D471/04; C07D491/048; C07D495/04; (IPC1-7): C07D471/04; A61K31/00; A61K31/505; C07D471/04; C07D495/04
Attorney, Agent or Firm:
Kazuo Sato (2 outside)