Title:
【発明の名称】融合トロパン誘導体、それらの製造及び使用
Document Type and Number:
Japanese Patent JPH11514638
Kind Code:
A
Abstract:
PCT No. PCT/EP96/04793 Sec. 371 Date Jun. 4, 1998 Sec. 102(e) Date Jun. 4, 1998 PCT Filed Nov. 4, 1996 PCT Pub. No. WO97/16451 PCT Pub. Date May 9, 1997The present invention discloses compounds of the formula, or any of its enantiomers or any mixture thereof, a pharmaceutically acceptable addition salt thereof or the N-oxide thereof wherein X and Y together forms =O, =S, =NOR2, =CR3R4, =N-CN, =N-NR7R8, -(CH2)m-, or -W'-(CH2)p-W''-, or one of X and Y is hydrogen and the other is -OR5, -SR5, or -NR5R6 Z is hydrogen, -COOR9; R3 and R4 are independently hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, aryl, arylalkyl, or -(CH2)q-COOR2; R2, R5 and R6 are independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, or arylalkyl, -CO-alkyl, or -SO2-alkyl; R7 and R8 are independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, aryl, or arylalkyl; R9 is alkyl, alkenyl or alkynyl; R1 is alkyl, alkenyl, alkynyl, aryl, or arylalkyl; where said aryl groups may be substituted one or more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino and nitro; W' and W'' are each independently O or S; n is 1, 2, 3, or 4; m is 2, 3, 4, or 5; p is 1, 2, 3, 4, or 5; and q is 0, 1, 2, 3,or 4. The compounds possess valuable properties as monoamine neurotransmitter, i.e dopamine, and serotonine, reuptake inhibitors.
Inventors:
Scale-Krugel, Jorgen
Olsen, Gunnar, M.
Nielsen, Elzebet, Ostergarde
Dar, Bujarne, Hugo
Jensen, Leif, Hert
Olsen, Gunnar, M.
Nielsen, Elzebet, Ostergarde
Dar, Bujarne, Hugo
Jensen, Leif, Hert
Application Number:
JP51708397A
Publication Date:
December 14, 1999
Filing Date:
November 04, 1996
Export Citation:
Assignee:
Neurosearch Actizel Scab
International Classes:
A61K31/00; A61K31/439; A61K31/46; A61P25/04; C07D451/02; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D471/08; C07D471/18; (IPC1-7): C07D451/02; A61K31/00; A61K31/46; C07D471/08
Attorney, Agent or Firm:
Akira Asamura (3 outside)