Title:
【発明の名称】官能的および空間的に多様な分子を製造するための分子骨格としての2-デオキシストレプタミンとその薬剤組成物
Document Type and Number:
Japanese Patent JPH11514980
Kind Code:
A
Abstract:
2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystreptamine with an almost infinite number of different groups ensures that the libraries so generated will be both spatially and functionally diverse. These compounds can then be screened for biological activity to afford lead compounds for pharmaceutical programs. Additionally, biological ligand mimics based on 2-deoxystreptamine can be readily appended, either directly or through a tether, to solid surfaces or incorporated covalently into gels to afford novel materials useful in separation science.
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Inventors:
Gustavson, Gary Earl
Powers, David G
Wonora, Mark A
Powers, David G
Wonora, Mark A
Application Number:
JP51146897A
Publication Date:
December 21, 1999
Filing Date:
September 06, 1996
Export Citation:
Assignee:
Script Jen Pharmaceuticals, Incorporated
International Classes:
C12Q1/70; A61K31/00; A61K31/155; A61K31/44; A61K31/4406; A61P31/00; A61P31/18; C07C215/44; C07C215/50; C07C217/58; C07C233/41; C07C233/79; C07C235/54; C07C257/18; C07C271/22; C07C271/24; C07C271/34; C07C275/26; C07C279/14; C07C279/22; C07C311/20; C07D207/32; C07D213/82; C07D401/14; C07D405/14; C07D498/04; C07K1/113; C08F8/30; C07B61/00; (IPC1-7): C07C215/44; A61K31/155; A61K31/44; C07C233/79; C07C271/24; C07C275/26; C07D213/82
Attorney, Agent or Firm:
Sakai Hajime