Document Type and Number:
Japanese Patent JPS5037663
Kind Code:
B1
Abstract:
21-Fluoro-steroids of the partial formula (I): (where R is H and R1 and R2 are H or hydrocarbyl or R1, R2 is a double bond) are prepd. in good yields by reacting steroids of partial formula (II) (where Z is H or an esterified carboxyl gp) with a diazo gp. transferring agent (e.g. a sulphonyl azide, an azidinium salt or a ditridiazoacetic acid ester, reacting the resulting diazo-steroid of partial formula (III) with HF and if desired, at any stage converting functionally modified OH gps. into free OH gps. or functionally modifying free OH gps. 21-Fluoro-3-(hydroxy or acyloxy)-pregna-5,16-dienes which are claimed per se, have antiviral activity. Other products are useful as intermediates for pharmacologically active fluorinated steroids.
Application Number:
JP12383770A
Publication Date:
December 04, 1975
Filing Date:
December 31, 1970
Export Citation:
International Classes:
A61K31/573; C07J5/00; C07J7/00; C07J75/00; (IPC1-7): C07J5/00