Document Type and Number:
Japanese Patent JPS5113149
Kind Code:
B1
Abstract:
1307436 Styrenes DR KARL THOMAE GmbH 4 Aug 1970 [5 Aug 1969] 37663/70 Heading C2C Compounds of the general Formula (I): (Ar=2-, 3- or 4-pyridyl, 2-quinolyl, 2-pyrazinyl, pyrimidyl or 5-(1,2,4-oxadiazolyl) optionally substituted by a C l -y alkyl group, 2-benzimidazolyl optionally substituted by a halogen atom or a OF or C 1-3 alkyl group, 5-isoxazolyl optionally substituted by a Ph or C 1-3 alkyl group, Ph, 2-furyl, 2-thienyl; R 1,2,4,5 = H, C 1-3 alkyl; R3 = H, C 1-3 alkoxy; R 6,7 =H, C 1-3 alkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, aralkyl or NR 6 R 7 = saturated monocyclic 5-7 membered ring optionally containing an oxygen or further nitrogen atom; n = 0, 1) and their acid addition salts, are prepared by (a) eliminating water from a compound of the Formula (II): (b) reacting a compound of the Formula (III): (R 8 = C 1-3 alkyl) with a compound of the Formula (IV): in the presence of a base, (c) reacting a compound of the Formula (V): with a compound of the Formula (VI): in the presence of a base, (d) reacting a compound of the Formula (VII): (X=H, COCH 3 ) with a compound of the Formula (VIII): (Y=halogen) in the presence of a base, (e) reacting a compound of the Formula (IX):) (Z = replaceable atom or group) with a compound of the Formula (X): or (f) reacting a compound of the Formula (XI): with a compound of the Formula (IV), optionally followed in each case by salt formation and/ or isomer separation. The above compounds are analgesics, sedatives, and muscle relaxants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
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Application Number:
JP13394073A
Publication Date:
April 26, 1976
Filing Date:
November 29, 1973
Export Citation:
International Classes:
A61K31/13; A61K31/135; A61P21/02; A61P25/04; A61P25/20; A61P25/28; A61P43/00; C07C67/00; C07C213/00; C07C213/02; C07C213/08; C07C217/18; C07C217/20; C07C217/22; C07C217/32; C07C217/62; C07D213/30; C07D213/64; C07D215/04; C07D215/14; C07D235/04; C07D239/26; C07D241/12; C07D243/00; C07D261/08; C07D267/02; C07D271/06; C07D295/08; C07D307/42; C07D333/16; C07D471/04; C07F9/40