Document Type and Number:
Japanese Patent JPS5125023
Kind Code:
B1
Abstract:
1292785 Esters of dexamethasone and betamethasone ISF SpA 19 April 1971 [17 Oct 1970] 22811/71 Heading C2U Novel steroids of the formula (wherein R 1 is a saturated or unsaturated hydrocarbon group of 8-14 carbon atoms and n is 3, 4, 5, 6 or 7) are prepared by reacting beta- W ethasone or dexamethasone, or an ester thereof e.g. a 21-mesylate, with the appropriate acid R 1 CH = CH(CH 2 ) n CO 2 H or a salt thereof. Suitable acids include oleic, linoleic, linolenic and arachidonic acids. Dexamethasone and betamethasone 21-mesylates are prepared from the free 21-ols and mesyl chloride. The novel steroids are stated to possess antiinflammatory activity, and they may be made up into pharmaceutical compositions with suitable carriers.
Application Number:
JP7992871A
Publication Date:
July 28, 1976
Filing Date:
October 12, 1971
Export Citation:
International Classes:
C07J5/00; A61K31/57; C07C; C07J; (IPC1-7): C07J5/00