Document Type and Number:
Japanese Patent JPS5134142
Kind Code:
A
Abstract:
A novel group of 18,18-difluorosteroids of the general formula (I) wherein St, R1 and R2 have the meanings given hereinafter is produced by a chemically novel process characterized in that a corresponding 18-oxo compound is treated with a compound of the formula F3SX, wherein X denotes a fluorine atom or an amino group derived from a secondary amine. The compounds of the invention are useful as pharmaceutical intermediates. A number of them are physiologically active and possess hormone-like properties, e.g. those of sexual and/or adrenocortical hormones, such as the gonadotropin-blocking, ovulation-blocking, androgenic, oestrogenic, progestagenic, anabolic, antioestrogenic, antiandrogenic, mineralocorticoid, glucocorticoid and antiinflammatory activity, and can be used in lieu of known hormones or agents possessing corresponding hormone-like properties.
Inventors:
MISHERU BIORA
YAROSURAFU KARUFUODA
YAROSURAFU KARUFUODA
Application Number:
JP7713775A
Publication Date:
March 23, 1976
Filing Date:
June 24, 1975
Export Citation:
Assignee:
CIBA GEIGY
International Classes:
C07J75/00; C07J1/00; C07J5/00; C07J7/00; (IPC1-7): A61K31/565; A61K31/57; C07J1/00; C07J5/00