Document Type and Number:
Japanese Patent JPS5136271
Kind Code:
B1
Abstract:
1291644 Substituted 1-indanecarboxylic acids, esters and salts BRISTOL-MYERS CO 30 Jan 1970 [31 Jan 1969] 4535/70 Heading C2C The invention comprises d-, l- and dl-compounds of formula and nontoxic pharmaceutically acceptable salts and C 1-6 alkyl and (up to C 8 ) tertiary amino alkyl esters thereof, wherein Y is H, Cl, Br, F, OH, C 1-6 alkyl, alkoxy or alkylthio, SH, CN, NO 2 or NH 2 . These compounds are prepared by reacting p - cyclohexylphenylsuccinic anhydride [from the acid, itself made via p-cyclohexylbenzaldehyde, diethyl p-cyclohexylbenzylidenemalon. ate and ethyl 3-cyano-3-(p-cyclohexylphenyl)- propionate] with a Friedel-Crafts catalyst in an inert organic solvent to give 5-p-cyclohexyl-3- oxoindan-1-carboxylic acid, and reducing the latter, and where desired producing the compounds where Y is other than H by standard substitution methods (optionally preceded or followed by esterification using the acid or acid chloride); including nitration, reduction of the nitro-compound and utilization. of the intermediate where Y is a diazonium group (II). Circhonidine and dehydroabietylamine salts are used in examples for optical resolution. The compound where Y=HS may be prepared by saponifying the intermediate in which Y= EtOCS 2 -(obtained from II). The intermediate of the above formula where Y=I is also mentioned. Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula, which are anti-inflammatory agents.
Application Number:
JP666874A
Publication Date:
October 07, 1976
Filing Date:
January 14, 1974
Export Citation:
International Classes:
A61K31/19; A61K31/195; A61K31/215; A61P19/06; A61P29/00; B01J27/00; C07B61/00; C07C51/00; C07C61/16; C07C61/40; C07C62/02; C07C62/14; C07C62/38; C07C67/00; C07C201/00; C07C205/55; C07C213/00; C07C219/12; C07C227/00; C07C227/04; C07C227/18; C07C229/50; C07C253/00; C07C255/57; C07C313/00; C07C319/14; C07C323/62; C07D211/46; (IPC1-7): C07C61/22; C07C69/74; C07C79/44; C07C101/04