Document Type and Number:
Japanese Patent JPS5212777
Kind Code:
B2
Abstract:
1375357 Corticoid 21-sulphobenzoate ROUSSEL UCLAF 21 May 1973 [19 May 1972] 24013/73 Heading C2U The invention comprises 6α-methylprednisolone 21-(m-sulphobenzoate) and its alkali metal salts. The salts are prepared from the corresponding 21-methanesulphonate by reaction with a di-(alkali metal) m-sulphobenzoate in the presence of an N-alkyl-amide (e.g. DMF), and may be converted to the free acid by passing over an acidic ion-exchange resin. The free acid may thereafter be resalified. 6α-Methylprednisolone 21-methanesulphonate is prepared from the free 21-ol by reaction with mesyl chloride. Antiinflammatory compositions for oral, parenteral, topical and rectal administration comprise a compound of the invention and a carrier.
Application Number:
JP5477473A
Publication Date:
April 09, 1977
Filing Date:
May 18, 1973
Export Citation:
International Classes:
A61K9/08; A61K31/56; A61K31/57; A61P29/00; C07J1/00; C07J5/00; C07J9/00; C07J31/00; A61K9/20; A61K; C07C; C07J; (IPC1-7): C07J31/00