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Document Type and Number:
Japanese Patent JPS535294
Kind Code:
B1
Abstract:
1347977 N - Substituted alkanolamines SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 1 Nov 1971 [4 Nov 1970] 52469/70 Heading C2C Novel N-substituted alkanolamines of the general formula wherein A is -(CH 2 ) m -, -CH=CH-, -(CH 2 ) p O-, -(CH 2 ) p S- or -SO 2 -NR-, m is 1, 2 or 3, p is 1 or 2, n is 3-10, R is a C 1-5 alkyl group and each of X and Y is a hydrogen or halogen atom, and acid addition salts thereof are prepared by condensing a halide of the general formula wherein Hal is a chlorine or bromine atom, with an alkanolamine of the general formula H 2 N(CH 2 ) n CH 2 OH, followed optionally by salifying the product. Pharmaceutical compositions having psychostimulant, antidepressant and analgesic activity comprise, as active ingredient, an N-substituted alkanolamine of the first general formula above or a physiologically tolerable acid addition salt thereof, together with a pharmaceutically acceptable carrier, and may be administered orally, rectally or parenterally. Reference has been directed by the Comptroller to Specification 1,119,329.

Application Number:
JP8753071A
Publication Date:
February 25, 1978
Filing Date:
November 02, 1971
Export Citation:
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International Classes:
C07D281/02; C07D311/88; C07C215/42; (IPC1-7): C07C91/06; C07D267/18; C07D281/12; C07D337/12



 
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