Japanese Patent JPS5429498

B2

1494757 1,3,4-Thiadiazolium compounds BASF AG 20 Feb 1975 [21 Feb 1974] 7106/75 Heading C2C The invention comprises novel compounds (I) in which (a) R2, R3, R4, R5 and R6 are identical or different and are hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 , at least one of the substituents R2 to R6 being different from hydrogen, and R1 is alkyl or 2 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (b) R1 is methyl optionally substituted by phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring when at least two of R2 to R6 are different from hydrogen, or, when R2, R3, R5 and R6 have the above meanings, R4 is hydrogen, fluorine, bromine, iodine, alkyl of 2 to 4 carbon atoms, alkoxy of 2 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 and at least one of R2, R3, R4, R6 and R6 is different from H, or (c) R2, R3, R4, R5 and R6 are each hydrogen when R1 is alkyl of 3 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring or when R1 is ethyl which is #-substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (d) R1 is methyl substituted by cycloalkyl of 3 to 6 carbon atoms in the ring when R2, R3, R4, R5 and R6 are each hydrogen or R2, R3, R5 and R6 are hydrogen and R4 is chlorine. They are made by reacting compounds (II) (obtained by reacting compounds III with R1NHNH 2 ; the free acids corresponding to III are also prepared as are compounds IV) with carbon disulphide or thiophosgene. Pharmaceutical preparations having anticonvulsive action contain (I) as active ingredient. Administration is preferably orally.

JP2107175A

September 25, 1979

February 21, 1975

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C07D285/12; A61K31/41; A61K31/433; A61P25/08; C07D285/125

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