NEW MATERIAL:T-23-III substance shown by the formulaI{properties of appearance: yellowish orange amorphous powder; specific rotatory power: [α]25D=4.3°(CH3OH, C=1.0wt%); melting point: 94W95°C, etc.}and T-23-IV substance shown by the formula II[properties of appearance: grayly white amorphous powder; specific rotatory power:[α]25D=273°(CH3OH, C=1.0wt%); melting point: 130W132°C, etc.].
USE: Having antitumor action, useful as an intermediate for compounds having various kinds of physiological activities by introducing diverse groups into OH group at the 11-position of the substance.
PROCESS: T-23-II substance shown by the formula III obtained by cultivating Streptomyces rishiriensis T-23 strain (FERM-P 6141) is dissolved in an organic solvent such as tetrahydrofuran, etc., cooled to -15°C, reduced with litium aluminum hydride, so that the side chain containing a cyclohexane ring at the 11- position of the compound shown by the formula III is removed to give a compound shown by the formulaIor II.
SETO HARUO
SUEDA NORIYOSHI
SUGITA MASANORI
NATORI KOSHIHEI
SASAKI TETSUO