MANUFACTURE OF PIPERAZINOPYRIMIDINE DERIVATIVE

Title:

MANUFACTURE OF PIPERAZINOPYRIMIDINE DERIVATIVE

Document Type and Number:

Japanese Patent JPS58150571

Kind Code:

A

Abstract:

1512101 Piperazino-pyrimidines PRODUITS CHIMIQUES UGINE KUHLMANN 8 Aug 1975 [9 Aug 1974] 33132/75 Addition to 1434544 Heading C2C Novel compounds (II) (including salts thereof) in which Z represents an alkyl group having 1 to 4 carbon atoms, R 1 represents a hydrogen atom or a methyl or ethyl group, and R 2 represents a linear alkyl group having 3 to 6 carbon atoms, an allyl, hydroxyethyl or cycloalkyl group having 3 to 8 carbon atoms, a benzyl or p-methoxyphenyl group and the -NR 1 R 2 residue may represent a morpholino group, are made by condensing the appropriate amines with 2,4,6-trichloro-5-methylthio-pyrimidine in a two-step process. Pharmaceutical prearations having antiemetic, neuroleptic, spasmolytic, analgesic and antiserotonine actions contain (II) as active ingredient.

Inventors:

JIERAARU RUWAZOO
JIEORUJIYU MACHIODA
RUNE MISHIE
PIEERU OBERIANNU

Application Number:

JP1729283A

Publication Date:

September 07, 1983

Filing Date:

February 04, 1983

Export Citation:

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Assignee:

UGINE KUHLMANN

International Classes:

A61K31/505; A61K31/535; A61P1/08; A61P25/04; A61P25/20; A61P43/00; C07D239/48; (IPC1-7): A61K31/505; A61K31/535; C07D239/48

Attorney, Agent or Firm:

Hideto Asamura

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