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Title:
【発明の名称】新ナフタレン誘導体の製法
Document Type and Number:
Japanese Patent JPS5920655
Kind Code:
B2
Abstract:
1474377 Naphthalene derivatives BEECHAM GROUP Ltd 20 Aug 1974 [11 Sept 1973] 42550/73 Heading C2C [Also in Division A5] Novel compounds II in which X is Cl, Br, OCH 3 , SCH 3 , or 1-4C alkyl; Y is -CHR 1 -CH 2 - or R 1 is H or CH 3 and A is -CO- or -CHOH-; excepting the known compound 4-(61-methoxy- 21-naphthyl)butan-2-one; are prepared by methylation of a compound VI with MeLi, followed where necessary by reduction of the -CO- group to a -CHOH- group or by base catalysed reaction of acetone with a compound VII to give a compound II where Y is -CH = CH- followed where necessary by reduction of the -CO- group to a -CHOH- group. 3 - (61 - Methoxy - 21 - naphthyl) - butyric acid is prepared by reaction of triethylphosphonoacetate with 2-acetyl-6-methoxynaphthalene to give ethyl 3-(61-methoxy-21-naphthyl)-2-butenoate; reduction of this with H 2 over Pd/C to give ethyl 3 - (61 - methoxy - 21 - naphthyl) - butyrate and hydrolysis with NaOH. Trans - 3 - (61 - methoxy - 21 - naphthyl) - 2- butenoic acid is prepared by hydrolysis of its ethyl ester with NaOH.

Inventors:
ANSONII UIRIAMU REIKU
KAARU JOON ROOZU
Application Number:
JP10376474A
Publication Date:
May 15, 1984
Filing Date:
September 09, 1974
Export Citation:
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Assignee:
BEECHAM GROUP PLC
International Classes:
A61K31/09; A61K31/085; A61K31/12; A61P29/00; C07C29/136; C07C29/143; C07C29/145; C07C29/40; C07C33/18; C07C33/28; C07C33/46; C07C41/00; C07C41/26; C07C43/23; C07C45/00; C07C45/26; C07C45/45; C07C45/46; C07C45/62; C07C45/66; C07C45/68; C07C45/72; C07C45/74; C07C49/213; C07C49/223; C07C49/245; C07C49/255; C07C59/64; C07C67/00; C07C313/00; C07C319/20; C07C323/19; C07C323/20; C07C323/22; (IPC1-7): C07C49/255; C07C45/29; C07C45/45; C07C45/64; C07C45/65
Attorney, Agent or Firm:
Akizawa Masamitsu



 
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