【発明の名称】キナゾリン誘導体及びその製造法

Title:

【発明の名称】キナゾリン誘導体及びその製造法

Document Type and Number:

Japanese Patent JPS6022714

Kind Code:

B2

Abstract:

Quinazoline derivs. of formula (I) and their acid addn. salts are novel cpds. (where A is or -NR2-CnH2n-NR3 n=2,3 or 4; R2,R3 are each H or 1-4C alkyl and R is phenyl (opt. substd. by one or more gps. chosen from 1-4C alkyl, 1-4C alkoxy, and methylenedioxy), furyl thienyl or 5-alkylthio-1,3,4-oxadiazole-2-yl. (I) have marked antihypertensive activity of prolonged duration. The oral LD50 in mice is >500 mg/kg and i.p. LD50 in rats is generally >500 mg/kg. The cpds. do not affect cardiac rhythm and may be used to treat all types of hypertension by oral, rectal or parteral administration.

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Inventors:

FUIRITSUPU MITSUSHERU JATSUKU MANYURII

Application Number:

JP5255177A

Publication Date:

June 03, 1985

Filing Date:

May 07, 1977

Export Citation:

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Assignee:

SYNTHELABO

International Classes:

A61K31/495; A61K31/505; A61K31/517; A61P9/12; C07D239/95; C07D317/00; C07D333/00; C07D401/04; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D413/14; (IPC1-7): C07D239/95; C07D401/04; C07D405/12; C07D405/14; C07D409/14; C07D413/12; C07D413/14

Attorney, Agent or Firm:

Aoyama

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