Title:
【発明の名称】ピリミジノアミノメチルエルゴリン誘導体の製法
Document Type and Number:
Japanese Patent JPS6027676
Kind Code:
B2
Abstract:
There are prepared compounds having good adrenolytic, hypotonic, analgesic, central-sedative and antiserotoninic activity of the formula III in which R denotes hydrogen or methyl; R1 and R2 in each case denote hydrogen, alkyl having 1 to 3 carbon atoms, methoxy or phenyl; R3 denotes hydrogen, halogen, alkyl or alkoxy having 1 to 3 carbon atoms, phenyl, cyano, nitro, amino, acylamino having 1 to 3 carbon atoms, carboxamido or carbalkoxy having 1 to 3 carbon atoms in the alkoxy group, trifluoromethyl or SO2-Y, where Y is hydroxyl, amino or methyl; and R4 denotes hydrogen or methoxy. These compounds are obtained by reaction of an appropriate 2-aminopyrimidine anion with an appropriate 8- beta -chloro-, bromo-, mesyl- or tosyl-methylergoline derivative. The reaction is carried out in an aprotic solvent, dimethylformamide or dimethyl sulphoxide is preferred. The reaction temperature is preferably 50-110 DEG C. Significantly improved reaction yields are obtained.
Inventors:
JURIANA ARUKARI
RUIJI BERUNARUDEI
JERUMANO BOSHISHIO
ARUFUREDO GUREESERU
ARUDEMIO TEMUPERIRI
RUIJI BERUNARUDEI
JERUMANO BOSHISHIO
ARUFUREDO GUREESERU
ARUDEMIO TEMUPERIRI
Application Number:
JP14460374A
Publication Date:
June 29, 1985
Filing Date:
December 18, 1974
Export Citation:
Assignee:
ERBA FARMITALIA
International Classes:
A61K31/48; A61P9/12; A61P25/02; A61P25/04; A61P25/20; A61P43/00; C07D457/02; (IPC1-7): C07D457/02
Attorney, Agent or Firm:
Yamashita White