Document Type and Number:
Japanese Patent JPS6119628
Kind Code:
B2
Abstract:
1449388 Hydrocinnamic acid nitriles F HOFFMAN-LA ROCHE & CO AG 8 Nov 1974 [8 Nov 1973 (2)] 05397/76 Divided out of 1449387 Heading C2C Novel compounds of Formula I wherein R1 and R2 are C 1-3 alkyl, R3 is halogen and R5 is an ether group a thioether group or an amino group derived from a primary or secondary amine are prepared by reaction of an appropriate benzaldehyde with a suitable propionitrile or by reaction of an α-(methylsulphonylmethyl)-benzyl alcohol with a suitable propionitrile. 4 - Chloro 3, - 5 - dimethoxy - α - (methylsulphonylmethyl) - benzyl alcohol is prepared by reduction od 41 - chloro - 31 ,51 - dimethoxy- 2-methyl sulphonyl acetophenone which is obtained by reaction of dimethylsulphone and ethyl 4 - chloro - 3,5 - dimethyoxybenzoate obtained by esterification of the acid. The benzaldehydes intermediates and obtained either from the corresponding acid chlorides or α - (methylsulphonylmethyl) benzyl alcohols. Intermediates prepared in preparation of above starting materials are the acid chlorides 3 - hydroxy - 5 - keto - 4 - phenylazo - 3 - cyclohexene carboxylic acid and its methyl ester, 3,5- dihydroxy - 4 - phenylazobenzoic acid, 3,5 - dimethoxy - 4 - phenylazobenzoic acid methyl ester, 4 - amino - 3,5 - dimethoxybenzoic acid methyl ester, 41 - amino - 31 ,51 - dimethoxy- 2 - methylsulphonylacetophenone and 3,5- dimethoxy-4-iodobenzaldehyde.
Inventors:
MATSUKUSU HOTSUFUAA
IWAN KOMUPISU
IWAN KOMUPISU
Application Number:
JP12724474A
Publication Date:
May 17, 1986
Filing Date:
November 06, 1974
Export Citation:
Assignee:
EFU HOFUMAN RA ROSHU UNTO CO AG
International Classes:
A61K31/505; A61P31/04; C07C37/50; C07C39/24; C07C45/41; C07C45/63; C07C47/575; C07C67/00; C07C245/06; C07C245/08; C07C253/00; C07C255/37; C07C255/53; C07D239/49; C07D295/145; C07D239/48