Document Type and Number:
Japanese Patent JPS6124395
Kind Code:
B2
Abstract:
NEW MATERIAL:A compound of formula I (Y is -O-, -S-; R1, R2 are H, lower alkoxy, halogen; R3 is H, lower alkyl, nitro; R4 is H, lower alkyl, lower alkoxycarbonyl). EXAMPLE:2-Benzyl-17-methoxy-8-oxo-11a-oxa-2-aza-C-homoerythrinan. USE:Analgesic: it has central nervous system depressant action. PREPARATION:For example, the thermal condensation reaction between of 4- piperidone of formula II (R9 is benzyl, phenethyl) such as ethyl 1-benzyl-4-piperidone-3-acetate and an amine of formula III such as 2-(2-methoxyphenoxy)-ethylamine is carried out in an inert organic solvent, then the product is cyclized with heat under acidic conditions.
Inventors:
MURAI HIROSHI
MATSUMURA SHINGO
MORITA IWAO
MAEHARA MITSUHIRO
SUNO KENJI
ENOMOTO HIROSHI
KIMURA KYOFUMI
KIMURA YUTAKA
MATSUMURA SHINGO
MORITA IWAO
MAEHARA MITSUHIRO
SUNO KENJI
ENOMOTO HIROSHI
KIMURA KYOFUMI
KIMURA YUTAKA
Application Number:
JP5703885A
Publication Date:
June 10, 1986
Filing Date:
March 19, 1985
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD
International Classes:
C07D498/20; A61K31/55; A61P25/00; A61P25/04; C07D209/00; C07D221/00; C07D267/00; C07D513/20
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