Document Type and Number:
Japanese Patent JPS6125356
Kind Code:
B2
Abstract:
NEW MATERIAL:Antibiotic substance C-19393S2. Appearance, white powder; specific rotatory power, [alpha]D<22>=-152+ or -15 deg. (c=0.5, water), molecular formula (estimation), C14H16N2Na2O9S2; solubility, insoluble in chloroform, ethyl acetate, etc., slightly soluble in ethanol, pyridine, etc., soluble in methanol, acetic acid, etc.; color reactions, positive to Ehrlich reaction, etc., negative to ninhydrin reaction, etc. USE:A remedy for infectious diseases, and an antiseptic agent. Effectice to gram- positive and gram-negative bacteria. Exhibits synergistic effect with penicillin or cephalosporin antibiotics. An intermediate of medicine. Stable at neutral pH range. PROCESS:Streptomyces sp.C-19393 (FERM-P No.4774) are cultured in a medium at 15-32 deg.C and about pH 4-8, for about 8-16hr. The cultivation product is separated into the supernatant liquid and the bacterial cells pref. by centrifugal separation. The objective substance can be obtained from the supernatant liquid or the cultivation product.
Inventors:
IMADA SATORU
HARADA SETSUO
ASAI MITSUKO
HARADA SETSUO
ASAI MITSUKO
Application Number:
JP1156079A
Publication Date:
June 14, 1986
Filing Date:
February 02, 1979
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
C07G11/00; A61K35/74; A61P31/04; C07D477/20; C12P1/06; C12P17/18; C12R1/465