Document Type and Number:
Japanese Patent JPS6129341
Kind Code:
B2
Abstract:
Optically active compounds of the formula: are prepared by reduction of optically active corresponding compounds of the formula: in which one R denotes an oxo or hydroxyl group, the other R denotes hydrogen or both Rs denote oxo groups or hydroxyl groups, with a hydride, at -70 to 125 DEG C and in an inert, aprotic solvent, or by resolution of the racemic compounds obtained from the reduction, using an optically active acid. In the formula I, the phenyl radical is unsubstituted or mono- or di-substituted by halogen, straight-chain C1-C6-alkyl, singly branched C1-C5-alkyl, C1-C6-alkoxy, trifluoromethyl, nitro, amino, acetamido and/or hydroxyl, X denotes hydrogen, straight-chain C1-C8-alkyl or a group CnH2nR1 where n = 1 to 3 and R1 = phenyl or p-fluorobenzoyl. The compounds are distinguished by an analgesic action; they can be used therapeutically as analgesics.
Inventors:
UIRIAMU JOOJIFU FUANSHO
JOOJIFU UIRIAMU EPUSUTAIN
RANTSU SUTEFUEN KURORII
KORISU MEIBERU HOTSUFUMAN
SHIDONII ROBAATO SAFUAA
JOOJIFU UIRIAMU EPUSUTAIN
RANTSU SUTEFUEN KURORII
KORISU MEIBERU HOTSUFUMAN
SHIDONII ROBAATO SAFUAA
Application Number:
JP11064777A
Publication Date:
July 05, 1986
Filing Date:
September 16, 1977
Export Citation:
Assignee:
AMERICAN CYANAMID CO
International Classes:
C07D209/02; A61K31/40; A61K31/403; A61P25/04; C07C29/147; C07C33/36; C07C61/28; C07C61/40; C07C62/34; C07D209/52; C07C; C07D
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