Document Type and Number:
Japanese Patent JPS61346
Kind Code:
B2
Abstract:
N-Acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin of the general formula (II) in which R<1> and R<2>, independently of each other, are selected from hydrogen, acyl and phosphorus-containing acyl, with the proviso that R<1> and R<2> are not both hydrogen and that, when R<1> or R<2> denotes acetyl, R<2> or R<1> is different from hydrogen and their non-toxic, pharmaceutically acceptable salts, are obtained by treating thienamycin with an appropriate acylating agent and converting the resulting compounds of the formula (II), where appropriate, into their non-toxic, pharmaceutically acceptable salts. The compounds which are obtained, and their pharmaceutically acceptable salts, are suitable for use as antibiotics.
Inventors:
RUISU BARASHU
BAATON JII KURISUTENSEN
JON HANNAA
UIRIAMU JEE REENZA
DEBITSUDO ETSUCHI SHIII
BAATON JII KURISUTENSEN
JON HANNAA
UIRIAMU JEE REENZA
DEBITSUDO ETSUCHI SHIII
Application Number:
JP13965076A
Publication Date:
January 08, 1986
Filing Date:
November 22, 1976
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
C07D477/00; A61K31/397; A61K31/40; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/495; A61K31/505; A61K31/655; A61K31/675; A61P31/04; C07D205/08; C07D477/20; C07D487/04; C07D498/04; C07F9/568; C07F9/6561
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