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Document Type and Number:
Japanese Patent JPS6139959
Kind Code:
B2
Abstract:
The invention provides novel esters of androstadiene 17-carboxyclic acids of the formula (I) wherein R' represents a hydroxyl group which is esterified with a carboxyclic acid having not more than 7 carbon atoms, R'' represents a methyl group in the alpha - or beta -position or the methylene group, wherein R is H or Cl, each of X and Y represents a hydrogen, chlorine or fluorine atom, with the proviso that at least one of these substituents is one of these halogens, when R is Cl, and that Y is only Cl or F and X only Cl, when R is H and that the androstadiene-17-carboxylic acid ester group does not contain more than 11 carbon atoms. The new esters have pronounced antiinflammatory action coupled with remarkably low systemic side effects on thymus, adrenals and body weight. They are especially suitable to be used in dermatology.

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Inventors:
YAROSURAFU KARUFUODA
Application Number:
JP1874377A
Publication Date:
September 06, 1986
Filing Date:
February 24, 1977
Export Citation:
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Assignee:
CIBA GEIGY
International Classes:
A61K31/56; A61P29/00; C07J3/00



 
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