Document Type and Number:
Japanese Patent JPS62884
Kind Code:
B2
Abstract:
The process produces pharmaceutical, cosmetic or diagnostic formulations by the freeze drying of one or more substances in solution or in suspension in a solvent or a mixture of solvents. The solution or suspension is locally and progressively cooled in a controlled manner while agitating so as to produce microcrystals of solvent which are put in suspension in the remainder of the liquid until there is obtained a high-viscosity microcrystalline complex system comprising essentially isolated microcrystals of solvent in intimate mixture with interstitial liquid phases having a high concentration of the initially present substances. The microcrystalline complex system is hardened by cooling and lyophilized. This process permits the obtainment of lyophilized formulations having a higher dissolving or dispersing rate and lyophilized compositions of normally incompatible substances.
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Inventors:
ANJERO AABEA
Application Number:
JP10903678A
Publication Date:
January 10, 1987
Filing Date:
September 05, 1978
Export Citation:
Assignee:
RABO* ERU RAFUON SA
International Classes:
A61K49/00; A01N1/02; A61K8/00; A61K8/04; A61K8/11; A61K9/14; A61K9/19; A61K9/20; A61Q19/00; A61Q90/00; B01D9/04; B01D43/00; F26B5/06; F26B7/00
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