Document Type and Number:
Japanese Patent JPS6332056
Kind Code:
B2
Abstract:
HCH:CH; Y1=H, OH, CO2H, CN, acyloxy, optionally substituded CONH2; X=CH:CH, C:C; m=0-3; n=0-10; n'1-5; k=1-3) and their pharamaceutically acceptive salts were prepd. Thus, II was treated with 2, 6-dicarboxypyridine N-oxide and ceric ammonium nitrate to give 82% I(R,R1=MeO, R2=OH, X=C: C, m=o, n=4, q=3, k=1) which inhibited the prodn. of the slow-reacting substance of anaphyaxis(SRS-A) by 88% at 10μM compared with eicosatetryaynoic acid which inhibited SRS-A by 56.9% at 10 μM in guinea prgs.
Inventors:
TERAO SHINJI
SHIRAISHI MITSURU
MAKI YOSHITAKA
SHIRAISHI MITSURU
MAKI YOSHITAKA
Application Number:
JP18662280A
Publication Date:
June 28, 1988
Filing Date:
December 27, 1980
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
C07C69/025; A61K31/047; A61K31/12; A61K31/122; A61P3/06; C07C27/00; C07C39/18; C07C45/00; C07C50/04; C07C50/06; C07C50/14; C07C50/28; C07C51/00; C07C59/76; C07C67/00; C07C231/00; C07C233/31; C07C235/78; C07C253/00; C07C255/31; C07C255/46