Japanese Patent JPS6337120

B2

Compounds of the formula (I) wherein R1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R2 represents a group COR6 where R6 is a C1-3 alkyl group or OR2 and R3 together form a 16 alpha ,17 alpha -isopropylidenedioxy group; R3 represents a hydrogen atom, a methyl group (which may be in either the alpha - or beta -configuration) or a methylene group; R4 represents a hydrogen, chlorine or fluorine atom; R5 represents a hydrogen or fluorine atom and symbol represents a single or double bond have good anti-inflammatory activity, particularly on topical applications. The compounds of formula I are prepared by esterification, halogenation, reduction, deprotection and reaction at a 9,11-double bond to form a 9 alpha -halo-11 beta -hydroxy grouping. Pharmaceutical compositions containing the compounds of formula I and methods for the use of the compounds are described and claimed.

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GOODON HANREE FUIRITSUPUSU
BURAIAN MAKUDONARUDO BEIN
KURISUTOFUAA UIRIAMUSON
IAN FUIRITSUPU SUTEIIPURUSU
SUCHUAATO BURUUSU REINGU

JP2079081A

July 22, 1988

February 13, 1981

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GLAXO GROUP LTD

A61K31/56; A61K31/58; A61P29/00; C07J3/00; C07J31/00; C07J41/00; C07J71/00

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