Title:
メチルコバラミン含有凍結乾燥製剤及びその製造方法
Document Type and Number:
Japanese Patent JPWO2004098614
Kind Code:
A1
Abstract:
The present invention provides a freeze-dried preparation containing a high content of methylcobalamin which is highly stable over time and can be used in high-concentration methylcobalamin therapy. Disclosed is the freeze-dried preparation containing methylcobalamin or a pharmacologically acceptable salt thereof and an excipient wherein the excipient is at least in an amorphous state. The freeze-dried preparation according to the present invention is characterized in that when the excipient comprises a sugar and a sugar alcohol, the excipient in the amorphous state is contained in an amount of at least 20% by weight, based on the total weight of the sugar and the sugar alcohol.
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Inventors:
Akira Kato
Nomura Akiko
Nomura Akiko
Application Number:
JP2005505980A
Publication Date:
July 13, 2006
Filing Date:
May 06, 2004
Export Citation:
Assignee:
EISAI CO.,LTD.
International Classes:
A61K31/714; A61K9/00; A61K9/19; A61K47/02; A61K47/10; A61K47/24; A61K47/26; A61P21/00; A61P25/00; C07H23/00
Domestic Patent References:
| JPS55113721A | 1980-09-02 | |||
| JPH11507945A | 1999-07-13 |
Other References:
JPN6009046958, ＡＩＣｈＥ Ｊｏｕｒｎａｌ, 2002, Ｖｏｌ．４８， Ｎｏ．６, ｐ．１１４０−１１４４
JPN6009046959, Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ, 1997, Ｖｏｌ．３， Ｎｏ．１, ｐ．３−８
JPN6009046960, Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ, 200304, Ｖｏｌ．２０， Ｎｏ．４, ｐ．６６０−６６７
JPN6009046959, Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ, 1997, Ｖｏｌ．３， Ｎｏ．１, ｐ．３−８
JPN6009046960, Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ, 200304, Ｖｏｌ．２０， Ｎｏ．４, ｐ．６６０−６６７
Attorney, Agent or Firm:
Yoshiyuki Inaba
Katsuro Tanaka
Shinji Oga
Katsuro Tanaka
Shinji Oga