Title:
心筋細胞の増殖方法
Document Type and Number:
Japanese Patent JPWO2005049822
Kind Code:
A1
Abstract:
The proliferation of cardiomyocytes is induced by expressing cyclin and CDK in the cardiomyocytes, and by suppressing the function or action of a Cip/Kip family protein or inhibiting the production of a Cip/Kip family protein. Among the Cip/Kip family proteins, it is preferable to suppress the function of p27 Kip1 or inhibiting the production thereof. As a recombinant vector to be used therefor, there is provided a vector comprising: (1) a cyclin gene; (2) a cyclin-dependent kinase gene; and (3) one or a plurality selected from the group consisting of a gene encoding a factor that inhibits the function or action of a Cip/Kip family protein and a nucleic acid sequence that inhibits the production of Cip/Kip family protein.
Inventors:
安達 三美
中山 敬一
北嶋 繁孝
高木 弘光
中山 敬一
北嶋 繁孝
高木 弘光
Application Number:
JP2005515664A
Publication Date:
June 07, 2007
Filing Date:
November 19, 2004
Export Citation:
Assignee:
アスビオファーマ株式会社
International Classes:
C12N15/09; A61K31/7088; A61K35/34; A61K35/76; A61K48/00; A61P9/00; A61P9/04; A61P9/10; A61P43/00; C07K14/47; C12N5/077; C12N5/10; C12N9/12; C12N15/113; A61K35/12
Other References:
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