Title:
（１，３−ジ置換インドリル）尿素誘導体の製造方法及びその製造中間体並びにその製造方法
Document Type and Number:
Japanese Patent JPWO2006035937
Kind Code:
A1
Abstract:
A process for the production of (1,3-disubstituted indolyl) urea derivatives represented by the general formula (1), characterized by reacting a 1-substituted-aminoindole derivative with a phenyl halocarbonate to form a carbamate derivative, subjecting the carbamate derivative to Mannich reaction with a secondary amine and formaldehyde to form a 3-aminomethylindole derivative represented by the general formula (6), and then reacting the derivative (6) with a peptide derivative; indole derivatives represented by the general formula (6) which are intermediates for the above process; and a process for the production of the indole derivatives.
Inventors:
Kaguya Genji
Kyoko Yasuoka
Kyoko Yasuoka
Application Number:
JP2006537835A
Publication Date:
May 15, 2008
Filing Date:
September 30, 2005
Export Citation:
Assignee:
Kowa Co., Ltd.
International Classes:
C07K5/08; A61K38/00; A61P9/10; A61P11/02; A61P11/06; A61P19/02; A61P25/04; A61P29/00; A61P35/00; A61P37/08; C07D209/04; C07D209/14; C07K5/083
Attorney, Agent or Firm:
Norio Saeki