Title:
タグ標識可能なカルシウムイオン検出蛍光プローブ
Document Type and Number:
Japanese Patent JPWO2017122799
Kind Code:
A1
Abstract:
【解決課題】優れた光退色耐性や速いＣａ２＋検出キネティックスを有し、なおかつ、任意の細胞内部位への局在化を可能とするカルシウムイオン検出蛍光プローブを提供すること。【解決手段】以下の一般式（Ｉ）で表される化合物又はその塩。【選択図】なし
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Inventors:
Kenzo Hirose
Daisuke Asanuma
Kohei Matsui
Rieko Tanaka
Daisuke Asanuma
Kohei Matsui
Rieko Tanaka
Application Number:
JP2017561193A
Publication Date:
November 01, 2018
Filing Date:
January 13, 2017
Export Citation:
Assignee:
National University Corporation Tokyo University
International Classes:
C07D493/10; G01N33/52; G01N33/84
Domestic Patent References:
| JP2015231364A | 2015-12-24 |
Foreign References:
| US20130196362A1 | 2013-08-01 | |||
| WO2015153813A1 | 2015-10-08 |
Other References:
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DESUO YANG ET AL.: "Functional analysis of G-protein coupled receptors using a new fluorescein lactone-based intracellul", ANALYTICAL METHODS, vol. 2, JPN6020050440, 2010, pages 295 - 298, ISSN: 0004418822
LI,D. ET AL: "Genetic Targeting of a Small Fluorescent Zinc Indicator to Cell Surface for Monitoring Zinc Secretio", ACS CHEMICAL BIOLOGY, vol. 10, no. 4, JPN6017010711, 9 January 2015 (2015-01-09), pages 1054 - 1063, XP055368211, ISSN: 0004418823, DOI: 10.1021/cb5007536
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama