Title:
小児急性リンパ性白血病の血液学的病期の判定補助方法
Document Type and Number:
Japanese Patent JPWO2018016474
Kind Code:
A1
Abstract:
小児急性リンパ性白血病（小児ALL）の血液学的病期の判定を補助するための方法、及びそれに使用できる体外診断用医薬品を提供する。小児ALLの血液学的病期の判定を補助する方法であって、（1）被験者の末梢血及び骨髄液のいずれか少なくとも一方の生体試料中のウイルムス腫瘍−１遺伝子（WT1）のmRNA量を入手するステップ（2）前記同試料中のGAPDH mRNA量を入手するステップ、及び（3）前記(1)及び(2)のステップでそれぞれ入手したWT1 mRNA量とGAPDH mRNA量との比に基づいて判定補助に必要な指標値を算出するステップを含む方法。
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Inventors:
Yoshihide Miyazaki
Umehara Yukari
Osaka Osamu
Kimiyoshi Suto
Umehara Yukari
Osaka Osamu
Kimiyoshi Suto
Application Number:
JP2018528547A
Publication Date:
May 09, 2019
Filing Date:
July 18, 2017
Export Citation:
Assignee:
Otsuka Pharmaceutical Co., Ltd.
International Classes:
C12Q1/68; C12Q1/6809; C12Q1/6851; C12Q1/686; C12Q1/6876
Foreign References:
| WO2014115779A1 | 2014-07-31 |
Other References:
HU WEN-TING, ET AL.: "Detection of WT1 gene by real-time quantitative PCR in childhood leukemia", J CLIN PEDIATR, vol. 26, JPN6017030494, 2008, pages 655 - 659, XP009515534, ISSN: 0004566744
坂本 勇一他: "当院におけるWT1mRNA定量検査施行症例の検討", 臨床病理, vol. 56, JPN6017030497, 2008, pages 278, ISSN: 0004566745
SHAO-YAN HU, ET AL.: "The Significance of detection WT1 expression in childhood acute leukemias", PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol. Volume 27, Issue 8, JPN6021030656, 23 September 2010 (2010-09-23), pages 581 - 591, ISSN: 0004566746
ADEL A HAGAG, ET AL.: "Prognostic Impact of WT-1 Gene Expression in Egyptian Children with Acute Lymphoblastic Leukemia", MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, JPN6021030658, 1 January 2016 (2016-01-01), pages 1 - 8, ISSN: 0004566747
坂本 勇一他: "当院におけるWT1mRNA定量検査施行症例の検討", 臨床病理, vol. 56, JPN6017030497, 2008, pages 278, ISSN: 0004566745
SHAO-YAN HU, ET AL.: "The Significance of detection WT1 expression in childhood acute leukemias", PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol. Volume 27, Issue 8, JPN6021030656, 23 September 2010 (2010-09-23), pages 581 - 591, ISSN: 0004566746
ADEL A HAGAG, ET AL.: "Prognostic Impact of WT-1 Gene Expression in Egyptian Children with Acute Lymphoblastic Leukemia", MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, JPN6021030658, 1 January 2016 (2016-01-01), pages 1 - 8, ISSN: 0004566747
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office