Title:
病原性グラム陰性菌に対するワクチン
Document Type and Number:
Japanese Patent JPWO2018147265
Kind Code:
A1
Abstract:
本発明は、III型分泌システムのV抗原又はその相同体タンパク質又はその一部もしくはそれをコードする遺伝子とCpGオリゴデオキシヌクレオチド(CpG ODN)アジュバントを含む病原性グラム陰性菌に対するワクチンを提供するものである。
Inventors:
Sadaharu Sawa
Ken Ishii
Hayamako Hamaoka
Yoshifumi Naito
Ken Ishii
Hayamako Hamaoka
Yoshifumi Naito
Application Number:
JP2018567436A
Publication Date:
November 21, 2019
Filing Date:
February 06, 2018
Export Citation:
Assignee:
Kyoto Prefectural University Corporation
National Research and Development Agency Pharmaceutical Infrastructure, Health and Nutrition Institute
National Research and Development Agency Pharmaceutical Infrastructure, Health and Nutrition Institute
International Classes:
A61K39/104; A61K39/02; A61K39/106; A61K39/112; A61K39/118
Domestic Patent References:
| JP2015028066A | 2015-02-12 |
Foreign References:
| WO2015041318A1 | 2015-03-26 |
Other References:
佐和貞治: "病原性グラム陰性菌のＩＩＩ型分泌−Ｖ抗原ワクチン・抗体療法の開発−", 京都府立医科大学雑誌, vol. 120, no. 9, JPN6018008868, 25 September 2011 (2011-09-25), pages 659 - 671, ISSN: 0004753209
SAWA, TEIJI ET AL.: "Active and passive immunization with the Pseudomonas V antigen protects against type III intoxicatio", NATURE MEDICINE, vol. 5, no. 4, JPN6018008870, April 1999 (1999-04-01), pages 392 - 398, ISSN: 0004753210
KRIEG A. M.: "Antiinfective Applications of Toll-like Receptor 9 Agonists", PROCEEDINGS OF THE AMMERICAN THORACIC SOCIETY, vol. 4, JPN6018008874, 2007, pages 289 - 294, XP055533121, ISSN: 0004753211, DOI: 10.1513/pats.200701-021AW
安倍伸幸 ほか: "CpG motifを用いた鼻咽腔粘膜免疫応答の誘導", 耳鼻免疫アレルギー, vol. 22, no. 4, JPN6018008871, December 2004 (2004-12-01), pages 31 - 36, ISSN: 0004753212
SAWA, TEIJI ET AL.: "Active and passive immunization with the Pseudomonas V antigen protects against type III intoxicatio", NATURE MEDICINE, vol. 5, no. 4, JPN6018008870, April 1999 (1999-04-01), pages 392 - 398, ISSN: 0004753210
KRIEG A. M.: "Antiinfective Applications of Toll-like Receptor 9 Agonists", PROCEEDINGS OF THE AMMERICAN THORACIC SOCIETY, vol. 4, JPN6018008874, 2007, pages 289 - 294, XP055533121, ISSN: 0004753211, DOI: 10.1513/pats.200701-021AW
安倍伸幸 ほか: "CpG motifを用いた鼻咽腔粘膜免疫応答の誘導", 耳鼻免疫アレルギー, vol. 22, no. 4, JPN6018008871, December 2004 (2004-12-01), pages 31 - 36, ISSN: 0004753212
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office