Title:
Ｓ１００Ａ９を標的とする免疫原性組成物
Document Type and Number:
Japanese Patent JPWO2018155457
Kind Code:
A1
Abstract:
Ｓ１００Ａ９に対する中和抗体の産生を誘導する抗原性ペプチドとキャリアタンパク質を含む免疫原性組成物を提供する。当該免疫原性組成物は、抗血栓効果を有し、かつ長期的な出血リスクを伴わない、安全性の高い抗血栓ワクチンとして使用することができ、血小板凝集が関与する血栓が形成される疾患の予防、特に、再発性虚血性脳卒中の予防に有用である。
Inventors:
Shimamura
Tomohiro Kono
Nakagami Keitoku
Ryuichi Morishita
Hideki Mochizuki
Akiko Tenma
Takako Ehara
Tomohiro Kono
Nakagami Keitoku
Ryuichi Morishita
Hideki Mochizuki
Akiko Tenma
Takako Ehara
Application Number:
JP2019501353A
Publication Date:
January 16, 2020
Filing Date:
February 20, 2018
Export Citation:
Assignee:
National University Corporation Osaka University
Fanpep Co., Ltd.
Fanpep Co., Ltd.
International Classes:
A61K39/00; A61K39/39; A61K47/42; A61P1/16; A61P7/00; A61P9/00; A61P9/10; A61P25/28
Domestic Patent References:
| JP2003509340A | 2003-03-11 | |||
| JP2015533485A | 2015-11-26 |
Foreign References:
| WO2017164409A1 | 2017-09-28 |
Other References:
WANG Y. ET AL.: "Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis.", JOURNAL OF CLINICAL INVESTIGATION, vol. 124, no. 5, JPN6018011376, 2014, pages 2160 - 2171, XP055386570, ISSN: 0004827437, DOI: 10.1172/JCI70966
WANG Y. ET AL.: "Myeloid-related protein-14 regulates deep vein thrombosis.", JCI INSIGHT, vol. Vol.2, No.11, e91356, JPN6018011377, 2 June 2017 (2017-06-02), pages 1 - 12, ISSN: 0004827438
DANN R. ET AL.: "Platelet-Derived MRP-14 Induces Monocyte Activation in Patients With Symptomatic Peripheral Artery D", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 71, no. 1, JPN6018011378, 2 January 2018 (2018-01-02), pages 53 - 65, XP085325643, ISSN: 0004827439, DOI: 10.1016/j.jacc.2017.10.072
WANG Y. ET AL.: "Myeloid-related protein-14 regulates deep vein thrombosis.", JCI INSIGHT, vol. Vol.2, No.11, e91356, JPN6018011377, 2 June 2017 (2017-06-02), pages 1 - 12, ISSN: 0004827438
DANN R. ET AL.: "Platelet-Derived MRP-14 Induces Monocyte Activation in Patients With Symptomatic Peripheral Artery D", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 71, no. 1, JPN6018011378, 2 January 2018 (2018-01-02), pages 53 - 65, XP085325643, ISSN: 0004827439, DOI: 10.1016/j.jacc.2017.10.072
Attorney, Agent or Firm:
Ryu Iwatani