Title:
ANTIBODY THAT RECOGNIZES SERUM AMYLOID A
Document Type and Number:
WIPO Patent Application WO/1997/006184
Kind Code:
A1
Abstract:
An antibody useful in the immunoassay on the basis of the agglutination of human serum amyloid A (SAA) which serves as a marker of inflammation, etc., and the use of this antibody. The antibody is a novel one which recognizes SAA and also has the activity of binding to SAA contained in the gel filtration fractions of molecular weights of 10 to 40 kD. Also, a reagent and method for the immunoassay of SAA and a method for purifying SAA by using this antibody are provided. This novel antibody having an excellent binding activity enables the assay of SAA based on the immunological agglutination thereof. This antibody is excellent in the titer against SAA and contributes not only to the specific assay of SAA at a high sensitivity but also to the widening of the assay scope.
More Like This:
Inventors:
EITOKU HIROMI (JP)
MAEKAWA HIROAKI (JP)
NEMOTO JIRO (JP)
WADA ATSUFUMI (JP)
MAEKAWA HIROAKI (JP)
NEMOTO JIRO (JP)
WADA ATSUFUMI (JP)
Application Number:
PCT/JP1996/002219
Publication Date:
February 20, 1997
Filing Date:
August 07, 1996
Export Citation:
Assignee:
EIKEN CHEMICAL (JP)
EITOKU HIROMI (JP)
MAEKAWA HIROAKI (JP)
NEMOTO JIRO (JP)
WADA ATSUFUMI (JP)
EITOKU HIROMI (JP)
MAEKAWA HIROAKI (JP)
NEMOTO JIRO (JP)
WADA ATSUFUMI (JP)
International Classes:
C07K16/18; G01N33/68; (IPC1-7): C07K16/18; G01N33/53; G01N33/577
Foreign References:
| JPS61191697A | 1986-08-26 |
Other References:
BIOPHYSICAL CHEMISTRY, Vol. 36, No. 4, 1992, HIROMI NAGATOKU et al., "Study (1st Report) on Serum Amyloid A(SAA)", p. 29-34.
BIOPHYSICAL CHEMISTRY, Vol. 37, No. 1, 1993, HIROMI NAGATOKU et al., "Study (2nd Report) on Serum Amyloid A(SAA)", p. 19-23.
BIOCHEMICAL JOURNAL, Vol. 263, (1989), ALISTAIR F. STRACHAN et al., "Human Serum Amyloid A Protein", p. 365-370.
PROC. NATL. ACAD. SCI. U.S.A., Vol. 89, (1992), L. MEEK et al., "Murine Serum Amyloid A3 is a High Density Apolipoprotein and is Secreted by Macrophages", p. 7949-7952.
BIOPHYSICAL CHEMISTRY, Vol. 37, No. 1, 1993, HIROMI NAGATOKU et al., "Study (2nd Report) on Serum Amyloid A(SAA)", p. 19-23.
BIOCHEMICAL JOURNAL, Vol. 263, (1989), ALISTAIR F. STRACHAN et al., "Human Serum Amyloid A Protein", p. 365-370.
PROC. NATL. ACAD. SCI. U.S.A., Vol. 89, (1992), L. MEEK et al., "Murine Serum Amyloid A3 is a High Density Apolipoprotein and is Secreted by Macrophages", p. 7949-7952.
Download PDF: