Title:
INTEGRIN EXPRESSION INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2001/056607
Kind Code:
A1
Abstract:
Integrin expression inhibitors and remedies for arteriosclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinitis or inflammatory diseases, anticoagulant agents and cancerous metastasis inhibitors based on the integrin inhibitory effect. Namely, integrin expression inhibitors containing as the active ingredient sulfonamide compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same wherein B represents optionally substituted C¿6-10? aryl or 6- to 10-membered heteroaryl wherein the ring may be partly saturated; K represents a single bond, -CH=CH- or -(CR?4b¿R?5b¿)¿m??b¿- (wherein R?4b¿ and R?5b¿ may be the same or different and each represents hydrogen or C¿1-4? alkyl; and m?b¿ represents an integer of 1 or 2); R?1¿ represents hydrogen or C¿1-6? alkyl; Z represents a single bond or CO-NH-; and R represents optionally substituted C¿6-10? aryl or 6- to 10-membered heteroaryl wherein the ring may be partly saturated.
Inventors:
WAKABAYASHI TOSHIAKI (JP)
FUNAHASHI YASUHIRO (JP)
HATA NAOKO (JP)
SEMBA TARO (JP)
YAMAMOTO YUJI (JP)
HANEDA TORU (JP)
OWA TAKASHI (JP)
TSURUOKA AKIHIKO (JP)
KAMATA JUNICHI (JP)
OKABE TADASHI (JP)
TAKAHASHI KEIKO (JP)
NARA KAZUMASA (JP)
HAMAOKA SHINICHI (JP)
UEDA NORIHIRO (JP)
FUNAHASHI YASUHIRO (JP)
HATA NAOKO (JP)
SEMBA TARO (JP)
YAMAMOTO YUJI (JP)
HANEDA TORU (JP)
OWA TAKASHI (JP)
TSURUOKA AKIHIKO (JP)
KAMATA JUNICHI (JP)
OKABE TADASHI (JP)
TAKAHASHI KEIKO (JP)
NARA KAZUMASA (JP)
HAMAOKA SHINICHI (JP)
UEDA NORIHIRO (JP)
Application Number:
PCT/JP2001/000713
Publication Date:
August 09, 2001
Filing Date:
February 01, 2001
Export Citation:
Assignee:
EISAI CO LTD (JP)
WAKABAYASHI TOSHIAKI (JP)
FUNAHASHI YASUHIRO (JP)
HATA NAOKO (JP)
SEMBA TARO (JP)
YAMAMOTO YUJI (JP)
HANEDA TORU (JP)
OWA TAKASHI (JP)
TSURUOKA AKIHIKO (JP)
KAMATA JUNICHI (JP)
OKABE TADASHI (JP)
TAKAHASHI KEIKO (JP)
NARA KAZUMASA (JP)
HAMAOKA SHINICHI (JP)
UEDA NORIHIRO (JP)
WAKABAYASHI TOSHIAKI (JP)
FUNAHASHI YASUHIRO (JP)
HATA NAOKO (JP)
SEMBA TARO (JP)
YAMAMOTO YUJI (JP)
HANEDA TORU (JP)
OWA TAKASHI (JP)
TSURUOKA AKIHIKO (JP)
KAMATA JUNICHI (JP)
OKABE TADASHI (JP)
TAKAHASHI KEIKO (JP)
NARA KAZUMASA (JP)
HAMAOKA SHINICHI (JP)
UEDA NORIHIRO (JP)
International Classes:
A61K31/00; A61K31/145; A61K31/18; A61K31/404; A61K31/4045; A61K31/438; A61K31/4439; A61K31/506; A61P7/02; A61P9/10; A61P17/06; A61P19/02; A61P19/10; A61P35/00; A61P35/04; C07D209/08; C07D209/12; C07D209/30; C07D209/34; C07D209/42; C07D215/38; C07D217/02; C07D217/22; C07D217/24; C07D311/04; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D409/14; C07D411/12; C07D417/12; C07D471/04; A61K45/06; (IPC1-7): A61K45/00; A61K31/404; A61K31/4439; A61K31/506; A61K31/437; A61K31/4178; A61K31/427; A61K31/4709; A61K31/47; A61K31/472; A61K31/501; A61K31/4725; A61K31/353; A61K31/416; A61K31/4025; A61P43/00; A61P9/10; A61P17/06; A61P35/00; A61P19/10; A61P29/00; A61P7/02; A61P35/04
Domestic Patent References:
| WO1999052493A2 | 1999-10-21 | |||
| WO1999035163A1 | 1999-07-15 | |||
| WO1998058902A1 | 1998-12-30 | |||
| WO1998044797A1 | 1998-10-15 | |||
| WO1997036859A1 | 1997-10-09 | |||
| WO1997036861A1 | 1997-10-09 | |||
| WO1997036862A1 | 1997-10-09 | |||
| WO1995007276A1 | 1995-03-16 | |||
| WO2000041469A2 | 2000-07-20 | |||
| WO2000038786A2 | 2000-07-06 | |||
| WO2000032575A1 | 2000-06-08 |
Foreign References:
| US5843906A | 1998-12-01 |
Other References:
See also references of EP 1258252A4
Attorney, Agent or Firm:
Furuya, Kaoru (Nihonbashi-Hamacho Chuo-ku, Tokyo, JP)
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