Title:
USE OF HEPATOCYTE NUCLEAR FACTOR 4Α(HNF4Α) FOR THE TREATMENT OF HUMAN MALIGNANT SOLID TUMORS THROUGH INDUCTION-DIFFERENTIATION THERAPY
Document Type and Number:
WIPO Patent Application WO/2009/109146
Kind Code:
A1
Abstract:
Use of hepatocyte nuclear factor 4α(HNF4α) for the treatment of human malignant solid tumors through induction-differentiation therapy is provided.
Inventors:
XIE WEIFEN (CN)
YIN CHUAN (CN)
LIN YONG (CN)
CHEN YUEXIANG (CN)
ZENG XIN (CN)
YIN CHUAN (CN)
LIN YONG (CN)
CHEN YUEXIANG (CN)
ZENG XIN (CN)
Application Number:
PCT/CN2009/071590
Publication Date:
September 11, 2009
Filing Date:
April 30, 2009
Export Citation:
Assignee:
UNIV PLA 2ND MILITARY MEDICAL (CN)
XIE WEIFEN (CN)
YIN CHUAN (CN)
LIN YONG (CN)
CHEN YUEXIANG (CN)
ZENG XIN (CN)
XIE WEIFEN (CN)
YIN CHUAN (CN)
LIN YONG (CN)
CHEN YUEXIANG (CN)
ZENG XIN (CN)
International Classes:
A61K38/17; A61P35/00; C12N15/11
Other References:
YIN, C. ET AL.: "Construction of recombinant adenoviruses carrying hepatocyte nuclear factor 4 a and evaluation of its effect on hepatoma gene expression.", CHIN. J. DIG., vol. 27, no. 5, 2007, pages 318 - 321
LAZAREVICH N.L. ET AL.: "Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors.", HEPATOLOGY, vol. 39, no. 4, 2004, pages 1038 - 1047
SPATH G.F. ET AL.: "Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes,acting as a morphogen in dedifferentiated hepatoma cells.", J CELL BIOL, vol. 140, no. 4, 1998, pages 935 - 946
LAZAREVICH N.L. ET AL.: "Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors.", HEPATOLOGY, vol. 39, no. 4, 2004, pages 1038 - 1047
SPATH G.F. ET AL.: "Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes,acting as a morphogen in dedifferentiated hepatoma cells.", J CELL BIOL, vol. 140, no. 4, 1998, pages 935 - 946
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (Xuhui, Shanghai 3, CN)
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