Title:
1,1’-ビナフタレン-2,2’ジオールとの包接錯体を介する2-(2-ピリジルメチルスルフィニル)-ベンゾイミダゾールの光学活性誘導体の製造方法
Document Type and Number:
Japanese Patent JP5097559
Kind Code:
B2
Abstract:
Process for the preparation of optically active derivatives of 2-(2-piridylmethylsulfinyl)-benzimidazole, or salts thereof, by resolution of the corresponding racemic derivatives of 2-(2-piridylmethylsulfinyl)-benzimidazole. The resolution is performed through the formation of inclusion complexes with (S)-(−) or (R)-(+)-[1,1′-Binaphthalene]-2,2′-diol in the presence of an amine, followed by the break of the inclusion complex by treatment with an hydroxide of an alkaline metal. The enantiomer of the derivative of 2-(2-piridylmethylsulfinyl)-benzimidazole may be obtained by extractions at a particular pH with a suitable organic solvent. The process allows to perform the resolution with high yields and high optical purity, without using neither toxic solvents nor chromatography.
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Inventors:
Coppi, Laura
Berengel Mimo, Ramon
Gasans Gillen, Yolanda
Medranol Perez, Jorge
Berengel Mimo, Ramon
Gasans Gillen, Yolanda
Medranol Perez, Jorge
Application Number:
JP2007557470A
Publication Date:
December 12, 2012
Filing Date:
February 22, 2006
Export Citation:
Assignee:
Esteve Kimika, S.A.
International Classes:
C07D401/12; C07B57/00
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori