Title:
【発明の名称】1,5―ベンゾチアゼピン―3―カルボン酸化合物
Document Type and Number:
Japanese Patent JP2808629
Kind Code:
B2
Abstract:
NEW MATERIAL:A compound shown by formula I {R<1> and R<2> are H, halogen, alkyl or alkoxy; R<3> is alkyl, (substituted)phenyl, (substituted) phenylalkyl, etc.; A is 1-4C alkylene; Z is-OR<7> (R<7> is H, alkyl, phenylalkyl, etc.), group shown by formula II (R<8> and R<9> are H, alkyl, phenylalkyl, etc.), group shown by formula III (p is 1-4; R<10> and R<11>=R<8> or R<9>) or group shown by formula IV [R<12> is R<8>, R<9> or (substituted) phenoxyalkyl; q is 0-4; r is 4-6]} or a salt thereof. EXAMPLE:2,3,4,5-Tetrahydro-4-oxo-5-(2-phenylethyl)-1,5-benzothiazepin- 3-acetic acid. USE:A drug. A preventive and remedy for circulatory diseases such as thrombosis, hypertension or cerebrovascular twitch or angina pectoris or myocardial infraction. PREPARATION:For example, a compound shown by formula V or a reactive derivative thereof is reacted with a compound shown by the formula ZH in an inert solvent in the presence of a condensation agent to give a compound shown by formula I.
More Like This:
Inventors:
OBATA MINORU
MORITA KENJI
AO EIBOKU
NAKAO TATSU
NAKAJIMA TOORU
MORITA KENJI
AO EIBOKU
NAKAO TATSU
NAKAJIMA TOORU
Application Number:
JP689789A
Publication Date:
October 08, 1998
Filing Date:
January 13, 1989
Export Citation:
Assignee:
YOSHITOMI SEIYAKU KK
International Classes:
C07D417/12; A61K31/55; A61K31/554; A61P3/00; A61P25/02; A61P25/28; A61P43/00; C07D281/10; C07D281/12; C07D417/06; (IPC1-7): C07D281/10; C07D417/06; C07D417/12
Other References:
【文献】仏国公開1469476(FR,A1)
Attorney, Agent or Firm:
Takamiya Castle Masaru