Title:
ＣＮＳ疾患を治療するための１－複素環イソクロマニル化合物およびアナログ
Document Type and Number:
Japanese Patent JP7023994
Kind Code:
B2
Abstract:
Disclosed are compounds of Formula (I):and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
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Inventors:
Rinhong Shie
Philip Gulin Jones
Kelly El Spear
Noel Aaron Powell
Taline Gee Hanania
Badim Alexandrov
Philip Gulin Jones
Kelly El Spear
Noel Aaron Powell
Taline Gee Hanania
Badim Alexandrov
Application Number:
JP2020018081A
Publication Date:
February 22, 2022
Filing Date:
February 05, 2020
Export Citation:
Assignee:
Sunovion Pharmaceuticals Inc.
PGI DRUG DISCOVERY LLC
PGI DRUG DISCOVERY LLC
International Classes:
C07D405/04; A61K31/397; A61K31/4025; A61K31/422; A61K31/4439; A61K31/453; A61K31/5377; A61P25/00; A61P25/18; A61P25/24; C07D405/14; C07D413/04; C07D413/14; C07D493/04
Domestic Patent References:
| JP2013512926A | ||||
| JP4253970A |
Foreign References:
| WO2013150173A1 | ||||
| WO2000076990A1 |
Other References:
SOYER, N.,Study of condensation reactions of 1,2,4,5-tetraformylbenzene in basic media,Bulletin de la Societe Chimique de France,1976年,(5-6, Pt. 2),pp. 914-920
KERFANTO, M. et al.,Aminolysis of halogen derivatives. Applications. III. Reaction of morpholine with gem-dihalo compounds. Preparation of carbonylderivatives. Synthesis of polyformyl-benzenes,Bulletin de la Societe Chimique de France,1966年,(9),pp. 2966-2971
REGISTRY(STN)[online],Entered STN: 21 Sep 2008,検索日:2021年1月27日,CAS 登録番号1050749-85-3
REGISTRY(STN)[online],Entered STN: 19 Sep 2008,検索日:2021年1月27日,CAS 登録番号1050509-40-4
三宅昭夫ら,1位置換イソクロマン及びイソチオクロマン誘導体の合成,武田研究所報,1982年,41(1/2),pp. 24-40
TOFFANO, M. et al.,Asymmetric routes towards polyfunctionalized pyrrolidines: application to the synthesis of alkaloid analogues,Tetrahedron Asymmetry,2003年,14(21),pp. 3365-3370
KERFANTO, M. et al.,Aminolysis of halogen derivatives. Applications. III. Reaction of morpholine with gem-dihalo compounds. Preparation of carbonylderivatives. Synthesis of polyformyl-benzenes,Bulletin de la Societe Chimique de France,1966年,(9),pp. 2966-2971
REGISTRY(STN)[online],Entered STN: 21 Sep 2008,検索日:2021年1月27日,CAS 登録番号1050749-85-3
REGISTRY(STN)[online],Entered STN: 19 Sep 2008,検索日:2021年1月27日,CAS 登録番号1050509-40-4
三宅昭夫ら,1位置換イソクロマン及びイソチオクロマン誘導体の合成,武田研究所報,1982年,41(1/2),pp. 24-40
TOFFANO, M. et al.,Asymmetric routes towards polyfunctionalized pyrrolidines: application to the synthesis of alkaloid analogues,Tetrahedron Asymmetry,2003年,14(21),pp. 3365-3370
Attorney, Agent or Firm:
Mutsumi Samejima
Shinagawa
Shinagawa