Title:
1-ACYLPIPERIDINE COMPOUND
Document Type and Number:
Japanese Patent JP3118090
Kind Code:
B2
Abstract:
PURPOSE: To provide a new metabolically stable compound useful for the treatment of diseases pertaining substance P, such as pain, central nervous system diseases, inflammation diseases, hypertension, or the like, as a substance-P- antagonistic agent.
CONSTITUTION: This compound is a compound represented by formula I, (wherein R1 is an aralkyl, aroyl, or the like; R2 is a cycloalkyl, aryl, or the like; R3 is H, an alkyl, or the like; R4 is an aryl or heteroaryl; X1 is methylene, ethylene, or the like; or a salt and/or a solvate X2 is an alkylene, carbonyl, or the like; and X3 is carbonyl, an oxo-lower alkylene, or the like) or a salt thereof, such as (2R, 4S)-2-benzyl-1-[3,5-bis-(trifluoromethyl)benzoyl]-N-(4- quinolylmethyl)-4-piperidinamine. The compound is obtained by, for example, condensing a compound represented by formula II, (wherein Y1 is -N(R3)-H) and a compound represented by formula Y2-X3-R4, [wherein Y2 is (reactive esterified) hydroxyl, or the like] in a solvent in the presence of a condensing agent, such as pyridine, or the like.
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Inventors:
Butter shilling
Sylphia Offner
Jim Yacht. Fernstra
Sylphia Offner
Jim Yacht. Fernstra
Application Number:
JP21409392A
Publication Date:
December 18, 2000
Filing Date:
August 11, 1992
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
International Classes:
A61K31/4427; A61K31/443; A61K31/4433; A61K31/445; A61K31/451; A61K31/452; A61K31/4523; A61K31/4525; A61K31/4535; A61K31/454; A61K31/47; A61K31/4709; A61P1/00; A61P11/08; A61P25/00; A61P25/04; A61P25/18; A61P25/20; A61P25/24; A61P25/26; A61P27/02; A61P29/00; A61P43/00; C07D211/58; C07D401/06; C07D401/12; C07D401/14; C07D405/12; C07D409/12; C07D471/04; C07D211/26; C07D; (IPC1-7): C07D211/58; A61K31/445; A61K31/4523; A61K31/4525; A61K31/4535; A61K31/454; A61K31/4709; C07D401/12; C07D401/14; C07D405/12; C07D409/12; C07D471/04
Attorney, Agent or Firm:
Aoki Akira (3 outside)