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Patent Searching and Data


Title:
1-BETA-D-ARABINOFURANOSYLCYTOSINE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS58140099
Kind Code:
A
Abstract:

NEW MATERIAL:A 1-β-D-araninofuranosylcytosine derivative shown by the formulaI.

USE: A drug to act specifically on a cancerous cell by oral medication, so-called prodrug.

PROCESS: A compound shown by the formula II and a tripeptide shown by the formula III (Z is N-protecting group such as carbobenzoxy, trifluoroacetyl, tertiary butyloxycarbonyl, phthalyl, formyl, p-toluenesulfonyl, or triphenylmethyl usable in common peptide synthesis) are subjected to common peptide forming reaction, to give a compound shown by the formula IV, which is subjected to a reaction of removal of N-protecting group, to give a compound shown by the formulaI.


Inventors:
AKIYAMA SHINICHI
TAKAHASHI TOSHIHIRO
MAEDA KOUJI
TAWARA YOSHIYUKI
Application Number:
JP2069982A
Publication Date:
August 19, 1983
Filing Date:
February 13, 1982
Export Citation:
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Assignee:
NISSHIN FLOUR MILLING CO
International Classes:
C07K9/00; A61K31/70; A61K38/00; A61P35/00; C07H19/06; C07K1/06; C07K1/10; C07K1/113; (IPC1-7): A61K31/70; C07H19/06
Attorney, Agent or Firm:
Chika Takagi (3 outside)