Title:
1-DEOXY ANALOG OF VITAMIN D-RELATED COMPOUND
Document Type and Number:
Japanese Patent JP2015212294
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide novel prodrugs of activated vitamin Dcompounds.SOLUTION: Prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the enzyme CYP24, low calcemic activity, and anti-proliferative activity. Specifically, these prodrugs are 1-deoxy prohormones of active Vitamin D analogs, e.g. analogs of calcitriol. This disclosure is also directed to pharmaceutical and diagnostic compositions containing the prodrugs of the invention, and to their medical use, particularly as prodrugs in the treatment and/or prevention of diseases.
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Inventors:
GARY H POSNER
LINDSEY C HESS
ALVIN S KALINDA
RACHEL D SLACK
SAHA UTTAM
PETKOVICH P MARTIN
LINDSEY C HESS
ALVIN S KALINDA
RACHEL D SLACK
SAHA UTTAM
PETKOVICH P MARTIN
Application Number:
JP2015136522A
Publication Date:
November 26, 2015
Filing Date:
July 07, 2015
Export Citation:
Assignee:
CYTOCHROMA INC
UNIV JOHNS HOPKINS
UNIV JOHNS HOPKINS
International Classes:
C07C401/00; A61K31/59; A61K31/592; A61K31/593; A61K45/00; A61P3/02; A61P3/10; A61P5/18; A61P5/20; A61P13/12; A61P17/02; A61P17/06; A61P19/08; A61P19/10; A61P25/08; A61P31/06; A61P35/00
Domestic Patent References:
| JP2002104995A | 2002-04-10 | |||
| JP2006503880A | 2006-02-02 |
Foreign References:
| WO2007105773A1 | 2007-09-20 | |||
| WO2004002996A1 | 2004-01-08 | |||
| WO2001028565A1 | 2001-04-26 |
Other References:
JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 17, JPN6016037976, 2009, pages 5505 - 5519, ISSN: 0003411933
JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 8, JPN6016037977, 2009, pages 2204 - 2213, ISSN: 0003411934
JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 8, JPN6016037977, 2009, pages 2204 - 2213, ISSN: 0003411934
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa