Title:
1-METHYLCARBAPENEM DERIVATIVE AND PREPARATION THEREOF
Document Type and Number:
Japanese Patent JP04117382
Kind Code:
A
Abstract:
NEW MATERIAL:A compound of formula I (R is lower alkyl; R1 is H, OH- protecting group; R2 is H, imino-protecting group; R" is H, carboxyl-protecting group).
EXAMPLE: (1R, 5S, 6S)-2-[(2S, 4S)-2-(dimethylthiocarbamoyl)pyrrolidin-4- ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid.
USE: A remedy for infectious diseases such as gram positive bacteria, gram negative bacteria, etc., and an additive for animal feeds.
PREPARATION: The reactive ester (salt) of an alcohol of formula II is reacted with a mercaptan compound of formula III preferably in the presence of an alkali metal carbonate.
Inventors:
Iwasaki, Tameo
Kondo, Kazuhiko
Horikawa, Kouji
Yamaguchi, Totaro
Matsushita, Tadahiro
Kondo, Kazuhiko
Horikawa, Kouji
Yamaguchi, Totaro
Matsushita, Tadahiro
Application Number:
JP1990000238426
Publication Date:
April 17, 1992
Filing Date:
September 06, 1990
Export Citation:
Assignee:
TANABE SEIYAKU CO LTD
International Classes:
C07D477/00; A61K31/397; A61K31/40; A61P31/04; C07D477/00; A61K31/397; A61K31/40; A61P31/00; (IPC1-7): A61K31/40; C07D477/00