10 BETA-ALKYNYLESTRENE DERIVATIVE AND ITS PRODUCTION

Title:

10 BETA-ALKYNYLESTRENE DERIVATIVE AND ITS PRODUCTION

Document Type and Number:

Japanese Patent JPS62158300

Kind Code:

A

Abstract:

6-Substituted 10 beta -alkynylestrene derivatives of formula (I): wherein X is hydrogen, C1-C4 alkyl or halogen; n is zero, 1 or 2; Y is an oxo group or a methylene group; the symbol @ indicates a single bond or a double bond; R1 is halogen, azido or a group wherein each of R3 and R4 is, independently, hydrogen or C1-C4 alkyl, or R1 may be divalent and is a C1-C6 alkylidene group; and R2 is hydrogen or, when R1 is halogen, R2 may also be the same halogen as R1, and the pharmaceutically acceptable salts thereof; are aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors and prostatic hyperplasia.

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Inventors:

FURANKO FUAUSUTEIINI
ENRIKO DEI SARURE
BUITSUTORIA BUIRA
PAORO RONBARUDEI

Application Number:

JP30024186A

Publication Date:

July 14, 1987

Filing Date:

December 18, 1986

Export Citation:

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Assignee:

ERBA FARMITALIA

International Classes:

A61K31/565; A61P35/00; C07J1/00; C07J21/00; C07J41/00; C07J71/00; C10L1/32; (IPC1-7): A61K31/565; C07J41/00

Attorney, Agent or Firm:

Chika Takagi

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