Title:
11-(置換フェニル)-エストラ-4,9-ジエン誘導体
Document Type and Number:
Japanese Patent JP3977462
Kind Code:
B2
Abstract:
The invention relates to a 11-(substituted phenyl)-estra-4,9-diene derivative of formula I wherein A is a residue of a 5- or 6-membered ring containing 2 heteroatoms which are not connected to each other and independently selected from O and S, the ring being optionally substituted with one or more halogen atoms, or A is a residue of a 5- or 6-membered ring wherein no double C-C bonds are present, containing 1 heteroatom selected from O and S, which heteroatom is connected to the phenyl group at the position indicated with an asterisk, the ring being optionally substituted with one or more halogen atoms; R1 is H or 1-oxo(1-4C)alkyl; R2 is H, (1-8C)alkyl, halogen or CF3; X is selected from (H,OH), O, and NOH; and the interrupted line represents an optional bond. The compounds of the invention have anti-glucocorticoid activity and can be used in treating or preventing glucocorticoid-dependent diseases.
Inventors:
Ronalde Hebejarde
Application Number:
JP21282496A
Publication Date:
September 19, 2007
Filing Date:
August 12, 1996
Export Citation:
Assignee:
Narmrose Fuennault Chap Organon
International Classes:
A61K31/58; C07J17/00; A61K31/565; A61K31/575; A61P3/00; A61P3/04; A61P3/08; A61P5/00; A61P5/44; A61P9/10; A61P9/12; A61P25/00; A61P25/20; A61P25/24; A61P25/26; A61P25/30; A61P27/02; A61P43/00; C07J1/00; C07J7/00; C07J9/00; C07J21/00; C07J33/00; C07J41/00; C07J71/00; C07J75/00; A61K; C07J
Foreign References:
| WO1995004536A1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura