Title:
1,1,1-トリフルオロ-2-ヒドロキシ-3-フェニルプロパン誘導体
Document Type and Number:
Japanese Patent JP5242691
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
Inventors:
Bailey, Jack
Hertel, Cornelia
Hunzikar, daniel
Learner, Christian
Opst Zander, Ulrike
Peters, Jens-Uwe
Friger, Philip
Schultz-Ghersh, Tanya
Hertel, Cornelia
Hunzikar, daniel
Learner, Christian
Opst Zander, Ulrike
Peters, Jens-Uwe
Friger, Philip
Schultz-Ghersh, Tanya
Application Number:
JP2010526248A
Publication Date:
July 24, 2013
Filing Date:
September 18, 2008
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D213/30; A61K31/404; A61K31/415; A61K31/416; A61K31/4174; A61K31/4192; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/4439; A61K31/4545; A61K31/47; A61K31/4709; A61K31/472; A61K31/4965; A61K31/497; A61K31/498; A61K31/50; A61K31/502; A61K31/505; A61K31/5377; A61K31/5383; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P5/38; A61P9/00; A61P9/12; A61P25/24; A61P43/00; C07D209/12; C07D213/64; C07D215/14; C07D217/02; C07D217/20; C07D231/12; C07D231/56; C07D233/64; C07D237/08; C07D237/28; C07D239/26; C07D241/12; C07D241/42; C07D249/18; C07D277/24; C07D277/62; C07D401/04; C07D401/06; C07D401/12; C07D403/12; C07D413/12; C07D417/04; C07D417/12; C07D471/04; C07D498/04
Domestic Patent References:
| JP2007506750A | ||||
| JP2005527555A |
Foreign References:
| WO2007040166A1 | ||||
| WO2006135826A1 | ||||
| DE10346939A1 | ||||
| WO2007087518A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito