Title:
インターロイキン-1β変換酵素のインヒビターとしての1,2-ジアゼパン誘導体
Document Type and Number:
Japanese Patent JP4499917
Kind Code:
B2
Abstract:
The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1beta converting enzyme ("ICE") inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-("IL-1"), apoptosis-, interferon-gamma inducing factor-(IGIF), or interferon-gamma-("IFN-gamma") mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-gamma production and methods for treating interleukin-1, apoptosis-, and interferon-gamma-mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.
Inventors:
Wannamaker, Marion W.
Charifson, Paul
Loafers, David Jay.
Murican, Michael Dee.
Charifson, Paul
Loafers, David Jay.
Murican, Michael Dee.
Application Number:
JP2000535629A
Publication Date:
July 14, 2010
Filing Date:
March 09, 1999
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07D243/02; A61K31/551; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/00; A61P7/04; A61P7/06; A61P9/02; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07D401/12; C07D401/14; C07D403/04; C07D405/12; C07D405/14; C07D243/04
Domestic Patent References:
| JP8337527A |
Foreign References:
| US5552400 | ||||
| US5716929 |
Attorney, Agent or Firm:
Hidesaku Yamamoto