Title:
1,2-ジ(環式基)置換ベンゼン化合物
Document Type and Number:
Japanese Patent JP4411283
Kind Code:
B2
Abstract:
A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis.
wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.
Inventors:
Tetsuya Kawahara
Makoto Kotake
Naoki Yoneda
Shinsuke Hirota
Oguro Rikatsu
Makoto Kotake
Naoki Yoneda
Shinsuke Hirota
Oguro Rikatsu
Application Number:
JP2005516735A
Publication Date:
February 10, 2010
Filing Date:
December 24, 2004
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
C07D205/04; A61K31/381; A61K31/382; A61K31/40; A61K31/407; A61K31/4418; A61K31/451; A61K31/452; A61K31/4525; A61K31/495; A61K31/496; A61K31/4965; A61K31/5375; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61P1/00; A61P1/04; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/06; A61P37/08; A61P43/00; C07D207/06; C07D207/12; C07D207/273; C07D207/325; C07D211/14; C07D211/16; C07D211/18; C07D211/38; C07D211/42; C07D211/46; C07D211/56; C07D211/58; C07D211/62; C07D211/70; C07D211/72; C07D213/36; C07D213/64; C07D213/75; C07D223/04; C07D233/04; C07D241/08; C07D241/18; C07D257/04; C07D261/08; C07D265/30; C07D265/32; C07D271/10; C07D277/28; C07D295/02; C07D295/03; C07D295/06; C07D295/067; C07D295/073; C07D295/08; C07D295/088; C07D295/096; C07D295/10; C07D295/12; C07D295/135; C07D295/14; C07D295/15; C07D295/155; C07D295/18; C07D295/20; C07D295/205; C07D307/52; C07D309/04; C07D309/14; C07D333/20; C07D335/02; C07D405/12; C07D413/02; C07D413/10; C07D413/12; C07D487/08
Foreign References:
| WO2002059108A1 | ||||
| WO2003089410A1 | ||||
| WO2003002554A1 |
Attorney, Agent or Firm:
Yoshiki Hasegawa
Shiro Terasaki
Kimoto
Shiro Terasaki
Kimoto