Title:
ゴナドトロピン放出ホルモンレセプター(GnRH)アンタゴニストとしての1,2,4-トリアジン-3,5-ジオン
Document Type and Number:
Japanese Patent JP2005500352
Kind Code:
A
Abstract:
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1, R2, R3a, R3b, R4, R5, and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
Inventors:
Pontillow, joseph
Guo, Zie Can
Wu, Don Pay
Guo, Zie Can
Wu, Don Pay
Application Number:
JP2003517033A
Publication Date:
January 06, 2005
Filing Date:
August 02, 2002
Export Citation:
Assignee:
Neurocline Biosciences, Inc.
International Classes:
C07D253/06; A61K31/53; A61P1/12; A61P5/02; A61P13/08; A61P15/00; A61P15/08; A61P15/18; A61P17/00; A61P17/02; A61P25/20; A61P35/00; A61P43/00; C07D253/075; C07D401/04; C07D409/04; (IPC1-7): C07D253/06; A61K31/53; A61P1/12; A61P5/02; A61P13/08; A61P15/00; A61P17/00; A61P17/02; A61P25/20; A61P35/00; A61P43/00; C07D401/04; C07D409/04
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita